Normally it is sufficient to email via an email server, that is reachable from the InterFormNG2 host, but if necessary you can also setup InterFormNG2 to use mail servers, that are only reachable via a remote client.
When you setup an email server in InterFormNG2, you can refer to a remote client via the location ID of the client.
For actual emailing you can e.g. use the Create PDF email component in the workflow.